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Convulsion, Non-Epileptic

MedGen UID:
148227
•Concept ID:
C0751056
•
Sign or Symptom
Synonyms: Convulsion, Non Epileptic; Convulsions, Non-Epileptic; Non-Epileptic Convulsion; Non-Epileptic Convulsions

Professional guidelines

PubMed

Scoping review and expert-based consensus recommendations for assessment and management of psychogenic non-epileptic (functional) seizures (PNES) in children: A report from the Pediatric Psychiatric Issues Task Force of the International League Against Epilepsy.
Reilly C, Jette N, Johnson EC, Kariuki SM, Meredith F, Wirrell E, Mula M, Smith ML, Walsh S, Fong CY, Wilmshurst JM, Kerr M, Valente K, Auvin S
Epilepsia 2023 Dec;64(12):3160-3195. Epub 2023 Oct 7 doi: 10.1111/epi.17768. PMID: 37804168
Management of psychogenic non-epileptic seizures: a multidisciplinary approach.
Gasparini S, Beghi E, Ferlazzo E, Beghi M, Belcastro V, Biermann KP, Bottini G, Capovilla G, Cervellione RA, Cianci V, Coppola G, Cornaggia CM, De Fazio P, De Masi S, De Sarro G, Elia M, Erba G, Fusco L, Gambardella A, Gentile V, Giallonardo AT, Guerrini R, Ingravallo F, Iudice A, Labate A, Lucenteforte E, Magaudda A, Mumoli L, Papagno C, Pesce GB, Pucci E, Ricci P, Romeo A, Quintas R, Sueri C, Vitaliti G, Zoia R, Aguglia U
Eur J Neurol 2019 Feb;26(2):205-e15. Epub 2018 Nov 29 doi: 10.1111/ene.13818. PMID: 30300463
Functional neurological disorders: mechanisms and treatment.
Lehn A, Gelauff J, Hoeritzauer I, Ludwig L, McWhirter L, Williams S, Gardiner P, Carson A, Stone J
J Neurol 2016 Mar;263(3):611-20. Epub 2015 Sep 26 doi: 10.1007/s00415-015-7893-2. PMID: 26410744

Recent clinical studies

Etiology

Scoping review and expert-based consensus recommendations for assessment and management of psychogenic non-epileptic (functional) seizures (PNES) in children: A report from the Pediatric Psychiatric Issues Task Force of the International League Against Epilepsy.
Reilly C, Jette N, Johnson EC, Kariuki SM, Meredith F, Wirrell E, Mula M, Smith ML, Walsh S, Fong CY, Wilmshurst JM, Kerr M, Valente K, Auvin S
Epilepsia 2023 Dec;64(12):3160-3195. Epub 2023 Oct 7 doi: 10.1111/epi.17768. PMID: 37804168
How to distinguish seizures from non-epileptic manifestations.
Leibetseder A, Eisermann M, LaFrance WC Jr, Nobili L, von Oertzen TJ
Epileptic Disord 2020 Dec 1;22(6):716-738. doi: 10.1684/epd.2020.1234. PMID: 33399092
The aetiology of psychogenic non-epileptic seizures: risk factors and comorbidities.
Popkirov S, Asadi-Pooya AA, Duncan R, Gigineishvili D, Hingray C, Miguel Kanner A, LaFrance WC Jr, Pretorius C, Reuber M
Epileptic Disord 2019 Dec 1;21(6):529-547. doi: 10.1684/epd.2019.1107. PMID: 31843732
Management of psychogenic non-epileptic seizures: a multidisciplinary approach.
Gasparini S, Beghi E, Ferlazzo E, Beghi M, Belcastro V, Biermann KP, Bottini G, Capovilla G, Cervellione RA, Cianci V, Coppola G, Cornaggia CM, De Fazio P, De Masi S, De Sarro G, Elia M, Erba G, Fusco L, Gambardella A, Gentile V, Giallonardo AT, Guerrini R, Ingravallo F, Iudice A, Labate A, Lucenteforte E, Magaudda A, Mumoli L, Papagno C, Pesce GB, Pucci E, Ricci P, Romeo A, Quintas R, Sueri C, Vitaliti G, Zoia R, Aguglia U
Eur J Neurol 2019 Feb;26(2):205-e15. Epub 2018 Nov 29 doi: 10.1111/ene.13818. PMID: 30300463
Functional neurological disorders: mechanisms and treatment.
Lehn A, Gelauff J, Hoeritzauer I, Ludwig L, McWhirter L, Williams S, Gardiner P, Carson A, Stone J
J Neurol 2016 Mar;263(3):611-20. Epub 2015 Sep 26 doi: 10.1007/s00415-015-7893-2. PMID: 26410744

Diagnosis

Scoping review and expert-based consensus recommendations for assessment and management of psychogenic non-epileptic (functional) seizures (PNES) in children: A report from the Pediatric Psychiatric Issues Task Force of the International League Against Epilepsy.
Reilly C, Jette N, Johnson EC, Kariuki SM, Meredith F, Wirrell E, Mula M, Smith ML, Walsh S, Fong CY, Wilmshurst JM, Kerr M, Valente K, Auvin S
Epilepsia 2023 Dec;64(12):3160-3195. Epub 2023 Oct 7 doi: 10.1111/epi.17768. PMID: 37804168
How to distinguish seizures from non-epileptic manifestations.
Leibetseder A, Eisermann M, LaFrance WC Jr, Nobili L, von Oertzen TJ
Epileptic Disord 2020 Dec 1;22(6):716-738. doi: 10.1684/epd.2020.1234. PMID: 33399092
The aetiology of psychogenic non-epileptic seizures: risk factors and comorbidities.
Popkirov S, Asadi-Pooya AA, Duncan R, Gigineishvili D, Hingray C, Miguel Kanner A, LaFrance WC Jr, Pretorius C, Reuber M
Epileptic Disord 2019 Dec 1;21(6):529-547. doi: 10.1684/epd.2019.1107. PMID: 31843732
Management of psychogenic non-epileptic seizures: a multidisciplinary approach.
Gasparini S, Beghi E, Ferlazzo E, Beghi M, Belcastro V, Biermann KP, Bottini G, Capovilla G, Cervellione RA, Cianci V, Coppola G, Cornaggia CM, De Fazio P, De Masi S, De Sarro G, Elia M, Erba G, Fusco L, Gambardella A, Gentile V, Giallonardo AT, Guerrini R, Ingravallo F, Iudice A, Labate A, Lucenteforte E, Magaudda A, Mumoli L, Papagno C, Pesce GB, Pucci E, Ricci P, Romeo A, Quintas R, Sueri C, Vitaliti G, Zoia R, Aguglia U
Eur J Neurol 2019 Feb;26(2):205-e15. Epub 2018 Nov 29 doi: 10.1111/ene.13818. PMID: 30300463
Psychogenic Non-Epileptic Seizures.
Chen DK, Sharma E, LaFrance WC Jr
Curr Neurol Neurosci Rep 2017 Sep;17(9):71. doi: 10.1007/s11910-017-0781-7. PMID: 28770498

Therapy

Scoping review and expert-based consensus recommendations for assessment and management of psychogenic non-epileptic (functional) seizures (PNES) in children: A report from the Pediatric Psychiatric Issues Task Force of the International League Against Epilepsy.
Reilly C, Jette N, Johnson EC, Kariuki SM, Meredith F, Wirrell E, Mula M, Smith ML, Walsh S, Fong CY, Wilmshurst JM, Kerr M, Valente K, Auvin S
Epilepsia 2023 Dec;64(12):3160-3195. Epub 2023 Oct 7 doi: 10.1111/epi.17768. PMID: 37804168
Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations.
Pearl NZ, Babin CP, Catalano NT, Blake JC, Ahmadzadeh S, Shekoohi S, Kaye AD
Adv Ther 2023 Sep;40(9):3626-3638. Epub 2023 Jun 27 doi: 10.1007/s12325-023-02586-y. PMID: 37368102
Pharmacotherapy for Dravet Syndrome.
Wallace A, Wirrell E, Kenney-Jung DL
Paediatr Drugs 2016 Jun;18(3):197-208. doi: 10.1007/s40272-016-0171-7. PMID: 26966048
GLUT1 deficiency syndrome: an update.
Gras D, Roze E, Caillet S, Méneret A, Doummar D, Billette de Villemeur T, Vidailhet M, Mochel F
Rev Neurol (Paris) 2014 Feb;170(2):91-9. Epub 2013 Nov 20 doi: 10.1016/j.neurol.2013.09.005. PMID: 24269118
Frontal lobe epilepsy.
Kellinghaus C, Lüders HO
Epileptic Disord 2004 Dec;6(4):223-39. PMID: 15634619

Prognosis

A reappraisal of the value of video-EEG recording in the emergency department.
Raucci U, Pro S, Di Capua M, Di Nardo G, Villa MP, Striano P, Parisi P
Expert Rev Neurother 2020 May;20(5):459-475. Epub 2020 Apr 4 doi: 10.1080/14737175.2020.1747435. PMID: 32249626
Diagnostic Biomarkers of Epilepsy.
Sueri C, Gasparini S, Balestrini S, Labate A, Gambardella A, Russo E, Leo A, Casarotto S, Pittau F, Trimboli M, Cianci V, Ascoli M, Cavalli SM, Ferrigno G, Aguglia U, Ferlazzo E
Curr Pharm Biotechnol 2018;19(6):440-450. doi: 10.2174/1389201019666180713095251. PMID: 30003857
Fibromyalgia and seizures.
Tatum WO, Langston ME, Acton EK
Epileptic Disord 2016 Jun 1;18(2):148-54. doi: 10.1684/epd.2016.0823. PMID: 27238051
Frontal lobe epilepsy.
Kellinghaus C, Lüders HO
Epileptic Disord 2004 Dec;6(4):223-39. PMID: 15634619
Myoclonus and epilepsies.
Fejerman N
Indian J Pediatr 1997 Sep-Oct;64(5):583-602. doi: 10.1007/BF02726110. PMID: 10771893

Clinical prediction guides

Non-HDL Cholesterol, Obesity, and Metabolic Syndrome in Epileptic Patients.
Khuda IE, Nazish S, Zeeshan MA, Shariff E, Aljaafari D, Alabdali M
Prim Care Companion CNS Disord 2022 Jun 7;24(3) doi: 10.4088/PCC.21m03057. PMID: 35687885
Diagnostic Biomarkers of Epilepsy.
Sueri C, Gasparini S, Balestrini S, Labate A, Gambardella A, Russo E, Leo A, Casarotto S, Pittau F, Trimboli M, Cianci V, Ascoli M, Cavalli SM, Ferrigno G, Aguglia U, Ferlazzo E
Curr Pharm Biotechnol 2018;19(6):440-450. doi: 10.2174/1389201019666180713095251. PMID: 30003857
Fibromyalgia and seizures.
Tatum WO, Langston ME, Acton EK
Epileptic Disord 2016 Jun 1;18(2):148-54. doi: 10.1684/epd.2016.0823. PMID: 27238051
Fixation-off sensitivity.
Brigo F, Rossini F, Stefani A, Nardone R, Tezzon F, Fiaschi A, Manganotti P, Bongiovanni LG
Clin Neurophysiol 2013 Feb;124(2):221-7. Epub 2012 Aug 24 doi: 10.1016/j.clinph.2012.07.017. PMID: 22925838
Bradycardia in neurosurgery.
Agrawal A, Timothy J, Cincu R, Agarwal T, Waghmare LB
Clin Neurol Neurosurg 2008 Apr;110(4):321-7. Epub 2008 Mar 7 doi: 10.1016/j.clineuro.2008.01.013. PMID: 18329164

Recent systematic reviews

Scoping review and expert-based consensus recommendations for assessment and management of psychogenic non-epileptic (functional) seizures (PNES) in children: A report from the Pediatric Psychiatric Issues Task Force of the International League Against Epilepsy.
Reilly C, Jette N, Johnson EC, Kariuki SM, Meredith F, Wirrell E, Mula M, Smith ML, Walsh S, Fong CY, Wilmshurst JM, Kerr M, Valente K, Auvin S
Epilepsia 2023 Dec;64(12):3160-3195. Epub 2023 Oct 7 doi: 10.1111/epi.17768. PMID: 37804168
The association of panic and hyperventilation with psychogenic non-epileptic seizures: A systematic review and meta-analysis.
Indranada AM, Mullen SA, Duncan R, Berlowitz DJ, Kanaan RAA
Seizure 2018 Jul;59:108-115. Epub 2018 May 19 doi: 10.1016/j.seizure.2018.05.007. PMID: 29787922
Neuroimaging studies in patients with psychogenic non-epileptic seizures: A systematic meta-review.
Mcsweeney M, Reuber M, Levita L
Neuroimage Clin 2017;16:210-221. Epub 2017 Jul 27 doi: 10.1016/j.nicl.2017.07.025. PMID: 28808618Free PMC Article
Psychological and psychiatric aspects of psychogenic non-epileptic seizures (PNES): A systematic review.
Brown RJ, Reuber M
Clin Psychol Rev 2016 Apr;45:157-82. Epub 2016 Mar 16 doi: 10.1016/j.cpr.2016.01.003. PMID: 27084446
Psychological and behavioural treatments for adults with non-epileptic attack disorder.
Martlew J, Pulman J, Marson AG
Cochrane Database Syst Rev 2014 Feb 11;2014(2):CD006370. doi: 10.1002/14651858.CD006370.pub2. PMID: 24519702Free PMC Article

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